Lifestyle

Decreasing DNA repair and genomic instability

The journal Oncotarget has published “Pim kinase inhibitor co-treatment decreases alternative non-homologous end-joining DNA repair and genomic instability induced by topoisomerase 2 inhibitors in cells with FLT3 internal tandem duplication” which reported that the serine/threonine kinase Pim-1 is upregulated downstream of FLT3-ITD, and inhibiting Pim increases topoisomerase 2 inhibitor chemotherapy drug induction of DNA DSBs […]

Lifestyle

New study examines long-term benefit of ‘two-midnight rule’

A new Health Affairs study led by Vanderbilt University Medical Center researchers raises questions about the long-term benefit and value of the so-called Medicare “Two-Midnight Rule” implemented in 2013 to reduce costly and potentially unnecessary inpatient hospital admissions. Led by Sabrina Poon, MD, MPH, assistant professor in the Department of Emergency Medicine, and Melinda Buntin, […]

Lifestyle

Dole recalls bagged salads over possible listeria​​ contamination

Dole Fresh Vegetables Inc. said Monday it has recalled bags of garden salad sold in 10 states after a bag tested positive for listeria contamination. No illnesses have been reported in connection with the recalled salad sold in Alabama, Florida, Georgia, Louisiana, Maryland, Massachusetts, North Carolina, Pennsylvania, South Carolina and Virginia, the company said in […]

Lifestyle

Imaging speeds lifesaving care to stroke victims

A commonly available imaging technique can identify stroke patients most likely to benefit from a procedure to restore blood flow, a potential breakthrough in care that could save thousands of lives every year, according to a study in Radiology. Large vessel occlusion strokes occur when a clot travels up from the heart or the neck […]

Lifestyle

Abnormal brain changes found to develop over time with bipolar disorder

Bipolar disorder (BD) is a debilitating psychiatric disorder characterized by fluctuating periods of depression and mania. Researchers have long suspected that BD may be accompanied by abnormal structural and functional changes in the brain. Small cross-sectional brain imaging studies of people with BD have shown hints at those changes, but the ability to interpret data […]

Lifestyle

Researchers identify key component of cellular malfunction leading to cancer

Malfunctioning of the so-called Hippo signaling pathway within animal cells leads to irregular activity of proteins that regulate genes involved in cell proliferation. Researchers have identified a key step in the process of this aberration, opening the door to new therapeutics for cancers such as head-and-neck squamous cell carcinoma and lung adenocarcinoma. Scientists have homed […]

Lifestyle

Traditional Samoan medicine found to be as effective as ibuprofen at reducing inflammation

A team of researchers from Samoa, New Zealand and the U.S. has found that the leaves of the Samoan tree, matalafi, are as good at relieving inflammation as ibuprofen. In their paper published in Proceedings of the National Academy of Sciences, the group describes how they first studied the plant leaves and then tested them […]